The agency expanded its warning from just chopped romaine to any and all forms of the lettuce.
"CDC is updating its advice to consumers".
Health officials say there is a lag time of two to three weeks between when someone falls ill and when it's reported to the CDC.
That brings the total number of cases to 172, the U.S. Centers for Disease Control and Prevention said.
But the last shipments of lettuce grown in the region in Arizona believed to be the source of the contamination were harvested on April 16. the CDC said, and the harvest season is over.
No sight of Ramazan moon in Saudi Arabia on Tuesday
The Islamic calendar, like the Jewish calendar, is a lunar calendar and the start of the month changes from one year to the next. According to reports on Saudi Arabian state TV, as published by Arab News, bad weather made observation of the crescent hard .
The agency indicated that it is unlikely that any lettuce from that region is still available in stores or restaurants because of its 21-day shelf life.
WEDNESDAY, May 16, 2018 Twenty-three more illnesses caused by an E. coli outbreak tied to tainted romaine lettuce were reported by USA health officials on Wednesday. The state health lab confirmed the link to the Yuma region, Rooney said.
Unless you know where the lettuce came from, consumers anywhere in the US who have any store-bought romaine lettuce at home should not eat it and should throw it away.
The CDC said 20 people had developed a severe outcome of E. coli infection called hemolytic uremic syndrome.
California still has the most cases, 39, followed by Pennsylvania (21); Minnesota (12); Idaho (11); New Jersey, Montana, Arizona, Alaska (eight each); Washington (seven); OH (six); NY and MI (five each); Georgia (four); Wisconsin, Tennessee, Massachusetts, Colorado (three each); Connecticut, Illinois, North Dakota (two each); Florida, Texas, Iowa, Kentucky, Louisiana, Mississippi, Missouri, Nebraska, Oregon, South Dakota, Utah, Virginia (one each).