"A lot of lovely, peaceful men have been the victims of the bullying of men", she declared, saying it was "an exciting time" for men in Hollywood. "If the movie's budget is $10 million, the (male) actor has to understand that if he is making $9.7 million, it is going to be hard for equality", Hayek added.
"The actors have to say: 'OK, time's up".
Weinstein's team has been dismissive of other claims-for example, when actress Lupita Nyong'o came forward with sexual harassment allegations of her own against the Hollywood producer. She is developing five movies, and they are all about women, she said.
The prestigious Cannes festival has come under criticism for failing to showcase more films by women directors. More than angrier, because I think we were already angry.
"Personally, as a woman that has been part of this community and has had to go through the struggles that all women have had to go through, it's an important step to see this happen", she said.
But a day after joining the 82-woman protest at the Cannes Film Festival, Hayek revealed change for women in Tinseltown is already happening.
"It's not just the producers", Hayek said.
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One actor, Benedict Cumberbatch, on Sunday said he would boycott film projects that do not pay women the same as their male co-stars.
In a lengthy statement, Weinstein apologised for his "boorish behavior" following a screening of "Frida" but claimed he never fought with Hayek on set and didn't recall some of her allegations.
Hayek went on, "It's a proven fact that women of colour are less listened to".
The actress said of herself and Nyong'o, who accused Weinstein of sexually harassing her back in 2011: "We are the easiest to get discredited. So, he went attacking the two women of colour, in hopes that if he could discredit us, he could then maybe discredit the rest", Hayek told Variety during Women In Motion panel discussion at Cannes.
In the wake of the scandals that have followed Weinstein's downfall, Hayek said men in Hollywood "are terrified" and that "predators are hiding".
"Men have the opportunity to rethink what it means to be a man, and with this comes a lot of freedom".