The Mariners announced later Sunday that Cano has a fractured fifth metacarpal.
Nicholas Castellanos is out of the starting lineup for the Detroit Tigers for Sunday's game against Seattle after he injured a finger on his left hand Saturday.
Cano was hit in the third inning against the Detroit Tigers by an 88 miles per hour fastball from Tigers left-hander Blaine Hardy.
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Utility man Andrew Romine replaced Cano at second base following the hit by pitch.
Cano, an eight-time All-Star, has hit.287 with four home runs and 23 RBIs so far this season. They didn't say anything about how long I might be out, but it is broken bad, so there might be surgery, " Cano said after the Mariners' 5-4 loss to the Tigers.
Robinson Cano chased Fulmer from the game in the fifth when he hit a 3-run home run to make it 6-2 Seattle. The Mariners are 22-16, sitting 1 1/2 games behind the Houston Astros in the AL West.