He noted that Turkey will spare no help in preserving the nuclear deal.
Merkel acknowledged worldwide concerns over Iran's influence in Syria, Iraq and Yemen, and its ballistic missile program, but underlined that these issues should be discussed with Tehran, without abandoning the nuclear deal.
Mr Macron was in Aachen, Germany to receive his medal, which was given to him for "his vision for a new Europe and reform of the European project", "unrelenting determination and commitment" and "decisive struggle against every form of nationalism and isolationism".
Iranian Foreign Minister is scheduled to meet with his German, French and British counterparts in Brussels on Monday to discuss the fate of the nuclear agreement.
That appears unlikely after U.S. Treasury Secretary Steven Mnuchin said on Tuesday that licenses for the planemaker and rival Boeing Co to sell passenger jets to Iran would be revoked.
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It includes more risqué lingerie, including cup-less bodysuits, half-cut bras, and open-back bikini bottoms. Vogue is reporting that the cuffs are on their way and they'll cost between $18 - $29.
Merkel has previously said Germany and its European partners would "do everything" to ensure Iran remains in the landmark 2015 nuclear deal, while Putin has voiced "deep concern" at the USA decision.
"It's time that European countries opened their eyes", Le Maire said on Europe 1 radio. Around 120 German firms have operations with their own staff in Iran, including Siemens, and some 10,000 German companies trade with Iran.
But the US ambassador in Berlin, Richard Grenell, said firms should question the morality of doing business with Iran.
The United Nations, Russia, France, Germany and Britain have also urged Israel and Iran to avoid any further escalation in Syria.
Macron, who received the Charlemagne award at Thursday's event, echoed many of Merkel's points in pushing for a European foreign and defense policy.
"If we always step away from multilateral agreements as soon as we don't like something about them, that would be a bad message for the world", Merkel added.