In the Spanish League they are going to play the postponed matches of the 34-th round.
Ramos returned for some redemption in the 95th minute of the match.
Los Blancos came out stronger in the second period as Real were awarded a penalty in the 58th minuter after Lucas Vasquez was tripped in the box.
"We have many games and some have to rest", Zidane was quoted saying by Goal.com.
The European champions have conceded first half goals in five of their last seven matches and this looks like a great value selection for Wednesday night's game. The Yellow Submarine are only three points ahead of Sevilla, however, who climbed back into the Europa League qualification spots with a well-deserved win over Real.
Real Madrid's personal rivalry with Barcelona couldn't transcend the bounds of sportsmanship as the former refused to give the newly crowned La Liga champions, a guard of honor before the kicking off the El Clasico. "But he was good, like the others, above all in the second half".
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"Sergio is our captain", he said.
Chance after chance went begging for the visitors who had only previously lost two La Liga fixtures since the turn of the year.
Ramos took responsibility but his shot hit the cross-bar to the delight of the home fans as the score remained 2-0.
Real struggled hugely under Sevilla's capacity to break at pace and play direct balls for the forwards to chase behind the centre-backs-with the opening goal coming from that same route.
Mayoral scored his seventh goal this season.
In the last minute of injury-time, Theo Hernandez was judged to have been pushed off-the-ball in the Sevilla box - up step Ramos, again. Ramos stepped up for the attempt.
It proved too little too late however, as Real were unable to find an equaliser in what was an incredibly disappointing night for Zinedine Zidane's men.