Today's clash will be the final time Barca midfielder Andres Iniesta plays in the fixture, having announced that he will leave the Catalans at the end of the season.
Iniesta, who is expected to complete a move to China, has been key in recent months but Valverde said there was no point trying to persuade the 33-year-old.
Barca sealed the La Liga crown with a 4-2 win at Deportivo La Coruna last Sunday, meaning pride is all that is at stake when they face third-placed Real at the Nou Camp. "It is a game with three points on the line, where the table will not change, but for us it is a game we have to play well and do everything possible to win".
Barcelona are on the verge of completing an unbeaten league campaign, but must overcome their biggest remaining obstacle at Camp Nou against the Los Blancos.
Ronaldo's first-half strike saw him equal Alfredo Di Stefano's long-standing record of 18 Madrid goals in El Clasico but he will have to wait until next season to surpass the Madrid icon.
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Salah is only the second non-European player to scoop the FWA prize after former Liverpool striker Luis Suarez - and the first African victor .
But the club are already planning for next season with the transfer window just weeks away from reopening. Ultimately the best team win it.
"We've already talked a lot about that and it certainly is not going to be important", Valverde said. Barca, in particular, have been careful in celebrating their domestic double, their players aware of the disappointment that lingers from their Champions League crash in the quarter-finals. Before the game it will be like that, but when it starts I do not think there will be little expectation.
Luis Suarez has claimed that Barcelona deserve to be La Liga champions due to their consistency throughout the season, despite their early Champions League exit.
However, Zidane has rejected that request, reiterating his team will not uphold the tradition because Barcelona failed to offer them the same courtesy in the first Clasico of the season in December, shortly after Real had won the Club World Cup. "I'm proud Barca keep signing players of such quality".
"He's a player we admire, not just any other player, and we all know how he is as a person", Zidane said.