Cosby, in a 2005 deposition read to jurors by a police detective, said he obtained seven prescriptions for quaaludes from his doctor in Los Angeles in the 1970s, ostensibly for a sore back, but added he did not use them himself because they made him exhausted.
The jury is expected to hear from a pair of drug experts on Thursday.
O'Neill said the information wasn't relevant given it dated to years before the alleged assault.
Jurors got a look Friday (Saturday NZT) at Bill Cosby's travel records as his lawyers made the case that he never visited his suburban Philadelphia mansion in the month he is accused of drugging and molesting a woman there. The famed comedian paid her almost $3.4 million in 2006. But he noted during the parties' arguments that the cases cited in Cosby's filing are not precedential rulings O'Neill can cite in his own decision. "Yes", Cosby lawyer Tom Mesereau retorted.
Prosecutors wound down their case earlier Wednesday, introducing the comedian's explosive testimony about giving quaaludes to women before sex - an old admission that's taken on new significance after a half-dozen women testified that he drugged and violated them.
Cosby said he gave Constand 1½ tablets of the cold and allergy medicine Benadryl to help her relax, then fondled her breasts and genitals, according to the police transcript, which also was read to the jury on Tuesday.
The drug was banned in the United States in 1982, the same year one of the women who testified, Janice Baker-Kinney, alleges Cosby knocked her out with pills she suspected to be Quaalude and then raped her.
On a day when only expert witnesses testified in Bill Cosby's retrial, prosecutor Stewart Ryan thoroughly grilled the defense's toxicology expert Dr. Harry Milman on Thursday.
"All the symptoms she described, the timing of the onset of the symptoms she described, is consistent with the ingestion" of Benadryl, said Rohrig, who also testified at Cosby's first trial last June.
"If it caused unconsciousness or an inability to move your arms or legs, then it wouldn't be an over-the-counter drug", Milman said.
Google to Introduce 'Chat' for Android to Compete with Apple's iMessage
RCS uses existing data connections, meaning that it should be able to offer the same features as the competition. Anil Sabharwal is the leader of the Chat project and is also the man behind the well-received Google Photos app.
Prosecutors rested their case after Rohrig got off the witness stand.
Judge Steven O'Neill won't allow Russell to testify about Constand's "millionaire" aspirations but says he can tell jurors that Constand spoke of wanting to become a broadcaster.
Cosby's lawyers are expected to call several people who worked for him, including an executive assistant and employees of his talent agency and publicity firm.
The statute of limitations for sexual assault crimes in Pennsylvania is 12 years.
Temple University academic advisor Marguerite Jackson maintains she knows Andrea Constand isn't telling the truth about her alleged 2004 encounter with Cosby.
A private investigator working for the defence said he attempted to serve Williams at least six times at her North Carolina home before sending her a FedEx package containing a subpoena and instructions to call Cosby's legal team.
Constand testified last week that after swallowing the pills she experienced double vision, slurred her words, had dry mouth, and her legs felt "rubbery", even paralyzed.
Regan testified the model told her she was drugged and raped by Cosby and was insistent that the story be included in her 2002 memoir, "No Lifeguard on Duty".
"What has Sheri got to do with this?"
As previously reported, Constand claims that Cosby drugged and molested her inside his Cheltenham, Pa., estate in January 2004.