Syrian state television says the country's air defenses shot down missiles targeting its Shayrat airfield late on April 16.
Big explosions were heard near Al Shayrat Air base in Homs province, and in eastern Qalamoun near Damascus where two other air bases are located, the Syrian Observatory for Human rights reported. The Syrian state television report did not, however, specify who may have fired the missiles.
Syria denied it was responsible for the attack, which killed at least 80 people.
Defense Secretary Mattis said at the time that no follow-up attacks were planned and that the Pentagon was careful to ensure the safety of Russian troops and Syrian civilians in the area.
Syrian state media is widely believed to exaggerate their claims of shooting down incoming missiles.
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Shayrat air base was targeted by U.S. forces in 2017 after a suspected chemical attack in Khan Sheikhoun that Washington blamed on the Syrian government.
According to the reporter, missiles crossed into Syria through Lebanon.
Near Damascus, the pro-regime media reported that three missiles had been launched at the Damir airbase close to the capital.
Asked about the incident, an Israeli military spokesman said: "We don't comment on such reports".
Before the US -led attack, Israeli warplanes had fired missiles on the T-4 airbase in the eastern countryside of Homs on April 9, killing 14 soldiers, including Iranian fighters.