The South Carolina Department of Corrections first posted about the "ongoing situation" late Sunday night.
He said no officers were wounded.
The Department of Corrections said that all corrections and law enforcement officers are safe and that the fights were over by 3 a.m. Monday.
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Of South Carolina's nine all-male, maximum-security prisons, Lee Correctional Institution is the largest.
State police were called to one of South Carolina's most risky prisons Sunday night. "The burden of this lies at the feet of the warden and the state of SC".
In March, inmates at the prison held an officer hostage after taking control of a dorm room, The State reported. Florence County EMS, Kershaw County EMS, Darlington County EMS, Lexington County EMS and Hartsville Rescue and a private ambulance service also responded. It is in Bishopville, S.C., about 40 miles east of Columbia, the capital.
As of April 16 at midnight, the SCDC website accounts for 1,266 inmates at Lee Correctional Institution. One of the two inmates accused of the crime said he killed them so he would be moved to death row.