Bush, 92, will "instead focus on comfort care" for unspecified health complications, according to a statement. "She is surrounded by a family she adores, and appreciates the many kind messages and especially the prayers she is receiving".
Family spokesman Jim McGrath announced on Twitter Sunday that Bush, 92, made the decision after consulting with her family and friends.
Although it's not yet known was Barbara's health condition is, people are already sending her their well-wishes on social media. She has six children, including former President George W. Bush.
She continued: "Also, George Bush has given me the world".
Bush, 92, is battling Chronic Obstructive Pulmonary Disease and congestive heart failure and has been hospitalized several times over the a year ago.
In January, Mrs. Bush and her husband were hospitalized at the same time.
Instagram to Soon Allow You To Download Your Own Data
How interesting that all those apps have one thing in common-they all have the Stories feature and want to keep improving on it. Users will then be able to wrap around their scribbles around the objects, but the technology is still far from flawless .
Both husband and wife have dealt with deteriorating health in recent years.
"Barbara and I are so sorry we can't be there for your Inauguration on January 20th", Bush wrote at the time.
The nation's 41s president also was hospitalized in 2015 in ME, where he and his wife spend summers at their home in Kennebunkport, after falling at home and breaking a bone in his neck.
Former first lady Barbara Bush attends day two of the Republican National Convention (RNC) at the Xcel Energy Center on September 2, 2008 in St. Paul, Minnesota. Her father was the publisher of McCall's and Redbook magazines.
The couple met at a Christmas dance in 1941, when Barbara Pierce was 16 and George Bush was 17.