For the majority of the first half, Sheffield United controlled the game, largely thanks to the team's early goal, which began with Mark Duffy's cross.
And he then thumped in a second from the penalty spot after the visitors made a quickfire start to the second half via Pierre-Michel Lasogga's towering header.
Historically, the North London derby isn't an easy game to predict.
Despite the early setback, the visitors held out for the remainder of the first period and were nearly level before the break, with Jamal Blackman superbly turning away Pontus Jansson's header. Up stepped Billy Sharp, the ex-Leeds United striker, and duly slotted home what proved to be the winning goal.
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Ezgjan Alioski had Leeds' first effort, firing a long-range shot wide.
From the free-kick after Evans' foul, however, substitute Pablo Hernandez - on for the dazed Kemar Roofe - sent a delicious cross into the box and Jansson met it with his head only for Blackman to make a stunning flying save.
The second-half stated out good for Leeds, as Pablo Hernandez was able to curl in a decent cross that Lasogga did very well to get a decent header from. Managers, players, directors and presidents may change, but you are the ones who remain, together and united. The Blades heaped some pressure on the Leeds net with plenty of corner kicks and a spell of possession that featured a decent shot from Duffy that went just over the net.
Kalvin Phillips and Eunan O'Kane returned to the Leeds line-up following suspension, the latter as captain.
Heckingbottom chats to Leeds director of football Victor Orta.. Latching on to an over-pushed ball from a Blades defender running out from the back, Hernandez advanced up the left touchline before cutting back in and placing a deft chipped cross onto the head of Pierre-Michel Lasogga.
Sheffield United: Blackman, Baldock, Basham, O'Connell, Stearman, Stevens, Evans (Lundstram), Fleck, Duffy (Leonard 77), Sharp (Holmes 89), Clarke.