Arsenal travel to Wembley, the temporary home of bitter cross-city rivals, Tottenham Hotspur, in what could be one of the biggest games of the season for both sides. In Accuscore simulations the hosts manage to score a hefty 2.31 goals on average, while visiting Arsenal scores 1.34 goals.
For Neutrals this should be a good game to watch, for city supporters however, this could be a routine victory or a shocking game where points are dropped at home.
Arsenal are aiming to win both home and away against their north London rivals in the Premier League for just the fourth time in the same season, doing so previously in 2004-05, 2007-08 and 2013-14. Mauricio Pochettino's side are capable of playing deeper, something they'd done more this season, but they're likely to start this match at a high tempo - they'll want to improve upon last weekend's sluggish start at Anfield.
Wenger also addressed the team's injuries.
Pochettino also has decisions to make at full-back. A fearsome midfield of he and Eric Dier may be the order of the day against Arsenal's multiple playmakers, but since Wanyama started against Newport, it will probably be Dier and Mousa Dembele. With six goals in six matches, he loves north London derbies.
Arsenal manager Arsene Wenger: "It is always a game that is charged emotionally".
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The key question here is the starting of Alex Iwobi, Alexandre Lacazette or Jack Wilshere.
Tottenham have shaken off their early teething problems at their temporary home and are unbeaten in their last 12 league games at Wembley - showing similar form to last season when they were invincible at the now demolished White Hart Lane.
He said: "Tottenham are a touch stronger at the moment but I do like the Arsenal forward line now".
Arsene Wenger's men bagged a massive 5-1 victory against Everton in the English Premier League (EPL) last week, riding on a memorable hat-trick by Aaron Ramsey. On the other hand, it's a crucial match for the Gunners whose top-four ambitions will be more or less crushed if they return with anything but a win. The Tottenham Hotspur manager will have been desperate to rest a number of his Spurs stars for Tuesday's Champions League clash against Juventus, but he simply can not.
That match was the only time Kane failed to find the net in the league against Arsenal, against whom he has scored six times in six league matches.
The race is definitely on for the Champions League, Arsenal's impressive win over Everton last week will count for nothing.