Kyle Alexander had 14 points, Admiral Schofield scored 12 and Jordan Bone added 10 as Tennessee (12-4, 3-2 Southeastern Conference) won its third straight in Volunteers coach Rick Barnes' 1,000th career game.
Barnes' 647 wins rank eighth among active Division I coaches.
After being ranked fifth in the nation at the start of SEC play, Texas A&M (11-6, 0-5) hasn't won since. Robert Williams had missed a loss at LSU last weekend due to illness. Chennedy Carter, the NCAA freshman leader in points per game - among many other stats - had 21. However, the Aggies, who got 16 points from Admon Gilder, 13 from DJ Hogg and 10 from Tonny Trocha-Morelos, have since gone into a slump.
Tennessee, which was plus-eight in turnovers at the half, went into intermission with a 36-28 lead.
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While it protected the ball better in the second half, turnovers tantalized A&M all night, as the Aggies committed 17 turnovers that Tennessee transitioned into 22 points. Williams chipped in 22 of her own while going 3-for-7 from 3-point range. He made just 3 of 13 shots from the field and didn't come close to duplicating his Vanderbilt performance, which was the highest-scoring Vols game in 15 years. After shooting 5 of 8 from beyond the arc in the first half, Texas A&M was just 3 of 12 in the second half. Tennessee again had a chance to win the game, but turned it over.
No. 6 Tennessee's undefeated record was snapped after a 79-76 overtime loss to No. 17 Texas A&M on Thursday.
Tennessee wasn't as effective in turning points into turnovers - 15 points from turnovers, compared to Texas A&M's 18.
Tennessee is at Missouri on Wednesday.