Illinois State Police were notified of a pursuit out of Wisconsin involving the bus, police said.
Greyhound said in a statement Friday night, "The bus with 50 customers onboard was en route from Milwaukee to Chicago when the incident began around 9:50 pm CST".
The pursuit crossed into IL and the bus eventually stopped near the exit ramp to Route 173. A person on the Greyhound bus made threats to harm passengers according to public safety radio transmissions.
Kenosha County, Wis., sheriff's Lt. Rory Zuerlein said his agency received a call around 10 p.m. that an armed passenger on the bus was threatening other riders, the paper reported.
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ISP say the suspect is in custody.
The chase began in southern Wisconsin and ended on Interstate 94 near the Wadsworth exit, according to a news release from the Illinois State Police.
Authorities said no injuries were reported.
Drivers are advised to avoid the area.