Overuse of ibuprofen could also lead to full-blown hypogonadism- or low testosterone levels - which has been linked to premature death. Ibuprofen has been shown to damage male fertility in athletes who regularly take the meds to manage pain, reported CNN. This indicates that they had developed a condition called "compensated hypogonadism", which happens when testosterone production is reduced, but the body is able to compensate by increasing LH levels, the researchers said.
One of the most commonly used drugs to get relief from pain is ibuprofen.
However, it's unknown whether the health effects of long-term ibuprofen use are reversible, he added.
In tests on 31 young men, two-week use of the drug affected levels of crucial male hormones, including testosterone.
In March of past year Jiri Dvorak, Fifa's former chief medical officer, warned of an "alarming trend" among elite football players to "abuse" legal painkillers such as ibuprofen.
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While this effect wasn't permanent, the researchers warned that prolonged use of ibuprofen by men could lead to low testosterone production - which might end up harming their fertility.
Dr David Kristensen, of Copenhagen University, said: "Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism" - a condition prevalent among elderly men and associated with reproductive and physical disorders".
Within 14 days, the luteinising hormones of men taking Ibuprofen, which are secreted by the pituitary gland and stimulate the testicles to produce testosterone, became coordinated with the level of ibuprofen circulating in their blood. You should never mix ibuprofen with alcohol or take more than the prescribed amount in a 24 hour period.
The study only focused on a small group of participants, so more research will be needed before the affects of ibruprofen are fully established.
"The effects were very mild even after six weeks of regular consumption of ibuprofen, which is longer than is usually recommended in practice, so this data should not concern men who occasionally take ibuprofen for pain relief".
The good news is that the problems required multiple weeks of constant ibuprofen use, so there's no indication that handling the odd muscle ache or hangover with ibuprofen will cause problems. It is worth noting that the study is actually a continuation of research looking into the effects of pain relievers on pregnant women.