Newcastle's tally of 15 points is their lowest after 17 matches of a top-flight season since 1988-89, when they went on to finish bottom.
However, midfielder Aaron Ramsey, has been ruled out for the next three weeks with a hamstring problem.
Arsene Wenger is looking to spark a turnaround in form with a routine victory against struggling Newcastle United.
The Magpies have not tasted victory since a narrow win over Crystal Palace towards the end of October and have since then lost seven of their last eight, only picking up one point during that run which came in a 2-2 draw with West Brom.
Rafael Benitez has a poor away record against Arsenal as well, having failed to win any game in six attempts (D2 L4), the most against any team.
Arsenal: In seventh place with 30 points, there's a chance the Gunners could move into the top four with a win. Lose, and they could be back in the drop zone.
Kick-off on Saturday is at 3pm, and the game isn't being shown on UK TV.
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Matt Ritchie. The Scot is without a doubt Newcastle's best attacking resource, with six assists this season, as many as the rest of his team combined.
"Mustafi is back in training", Wenger told reporters at a pre-match press conference held at London Colney on Friday morning, per football.london.
Their chances appear slim despite Arsenal's recent disappointments, however, considering the Gunners have only conceded seven goals at the Emirates this season and Newcastle have scored the same amount in eight away trips.
Newcastle have gone on to open the scoring in defeats at Chelsea and Man United - so maybe - just maybe, an early goal for the visitors might cause the home fans to voice their displeasure - making it a tough atmosphere for Wenger's men.
Jonjo Shelvey will miss the game after being sent off against Everton, but other than that, Benitez has a full squad to pick from.
Newcastle United will face Arsenal at the Emirates Stadium in the Premier League this weekend.
With Aaron Ramsey out injured, this gives Arsene Wenger the flawless opportunity to give Jack Wilshere his second Premier League start of the season.