The last time it happened was on December 27, 2008, at UFC 92, where 205-pound champion Forrest Griffin lost the title to Rashad Evans via TKO, while interim heavyweight champion Antonio Rodrigo Nogueira was stopped for the first time in his career by Frank Mir.
Prior to the two colliding in the Octagon, the UFC President in Dana White had stated the the victor of the bout would be getting a shot at UFC Heavyweight Champion Stipe Miocic.
It's unclear which of the two title fights would serve as the UFC 220 main event. With additional reports confirming the news, it appears to be a done deal.
Miocic (17-2) will bid to become the first fighter in UFC history to successfully defend the heavyweight title three times when he takes on Francis Ngannou (11-1), who has earned his shot after a spectacular performance on Saturday night at UFC 218.
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UFC 220 now features one other title fight, a light heavyweight championship showdown between Daniel Cormier and fast-rising contender Volkan Oezdemir. He tied the record with a first-round knockout of Junior dos Santos at UFC 211 in Dallas on May 13. In his last bout, he stiffened Alistair Overeem in the first round with a thunderous left hand.
Then, in the post-fight interview, Ngannou said he is the real world champion and that Miocic was simply holding the belt for him in the interim.
In short: don't bet on the UFC 220 main event going five rounds.
THE UFC TITLES in the light-heavyweight and heavyweight divisions both look set to be up for grabs when the organisation returns to Boston's TD Garden early in 2018.