Mayfield also won the Walter Camp and Maxwell Award as player of the year as well as the Davey O'Brien Award as the top quarterback.
Mayfield passed for 4,340 yards and 41 touchdowns to lead the Sooners (12-1) to the No. 2 national ranking and into the College Football Playoff.
Ohio State quarterback J.T. Barrett and Oklahoma State's Mason Rudolph were beaten out by Mayfield for the O'Brien Award.
The O'Brien Award was initially given to the top player in the Southwest before going to a quarterback-only honor in 1981. Jason White won in back-to-back years in 2003 and 2004, while Sam Bradford earned the title in 2008. OU players have claimed 20 percent of the awards, and no other school has produced more than two honorees. I have to give a lot of the credit to my teammates and coaches, they are the reason that I am in position to win this award and I could not have done it without them. Never again, though. When he was asked about it by the media on Wednesday, Mayfield smiled and said, "I don't think I'll be doing that".
The University of Oklahoma football program is heading back to Norman with plenty of hardware in hand after Thursday night's Home Depot College Football Awards in Atlanta. "I am so appreciative of Mr. Hornung and the Louisville Sports Commission for selecting me for this very special honor". He has also rushed for 310 yards and another five scores with no fumbles lost.
"He's the leader of our team, I know everyone in Sooner Nation is proud of Baker and what he's done", Oklahoma coach Lincoln Riley said. I also want to thank our unbelievable fans at Penn State.
Mayfield is a former walk-on who has led the No. 2 Sooners to the College Football Playoff, where they will play No. 3 Georgia in the Rose Bowl on January 1. The game will be televised by ESPN.
Health officials: Flu shot may only be 10% effective this season
For the elderly or others who are especially vulnerable, a doctor may prescribe an antiviral medication to help lesson symptoms. According to the Centers for Disease Control and Prevention , several strains of influenza virus are in circulation.