The Champions League group stage wraps up on Wednesday, Dec. 6.
Atletico Madrid needs a lot to happen to keep alive its streak of four consecutive appearances in the knockout stage.
Chelsea will need a win to assure themselves of top spot in the group.
The west London side came from behind to rescue a 1-1 draw with top-six rivals Liverpool FC at Anfield last weekend after Willian cancelled out Mohamed Salah's opener.
Former Chelsea star Michael Essien believes the side's Premier League title ambition is far from over, despite now trailing leaders Manchester City by 11 points.
Manchester City have already won group F ahead of their final game against Shakhtar Donetsk.
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Leipzig still has a chance to progress on its European debut but needs a favor from Monaco at Porto in Group G. Leipzig, which is level on points with Porto, hosts group victor Besiktas on Wednesday and will only go through if it secures more points than the Portuguese team. To qualify in first place, Liverpool need a win or a draw if Sevilla fail to win at NK Maribor. If both teams draw, Dortmund will finish third due to their superior goal difference.
Germany's fourth team, Hoffenheim, didn't make the group stage after losing in the playoffs to Liverpool. Filling out the rest of the bracket and who takes four of the eight group victor spots is still in play.
But the focus on Tuesday's games will be on the fate of Atletico Madrid which hangs by the slenderest of threads.
Amid sluggish ticket sales, Roma coach Eusebio Di Francesco has been urging fans to show up at the Stadio Olimpico.
Shakhtar need a point to secure their progress to the round of 16.
Spurs finished as group winners with holders Real Madrid qualifying as runners-up. The Scottish champions will instead turn their attentions to finishing third and claiming a place in the Europa League after Christmas.