Mane will be out of action for up to six weeks following a hamstring injury deep into the dying embers of Senegal's 2 - 0 qualifying stage win on Saturday. But Mane missed the end of Liverpool's last campaign with a knee injury and was also away in January for the Africa Cup of Nations.
He has already missed three domestic matches this season after receiving a suspension following his sending off at Manchester City last month.
"When you are Jurgen Klopp facing games like the ones coming up, very tricky, very important ones, you need your best assets to put into the starting XI".
The first game he will miss will be the visit of Manchester United this Saturday, and Nicol does not think Liverpool will be able to cope without him.
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And Ginola highlights how the loss of Mane will impact heavily on the team. His talents are vital to the team, and without him their chances of taking a good points haul from their games with United and Spurs are severely less.
Though now seventh in the table, Liverpool are only a point behind fourth-placed Chelsea and two behind Spurs in third.
The former Red Bull Salzburg man netted 13 goals in 27 Premier League appearances last term, and has scored three in four so far this season.