We also know that Denmark and Italy will take part in the play-offs. Having reached the semi-finals of Euro 2016 against all odds, Wales' 60-year wait for a place at the World Cup continues as they were beaten 1-0 by the Republic of Ireland in a winner-takes-all showdown for a playoff place for Russian Federation.
In the absence of injured duo Seamus Coleman and Jonathan Walters, the 28-year-old captained his side to a memorable 1-0 victory over Wales, but picked up his second booking of the campaign to rule him out of his country's next game.
The eight teams in the play-offs are seeded by Fifa World Ranking, rather than by the number of points they accumulated in their group.
Greece and Sweden are also nearly certain to qualify for the play-offs - the Greeks simply need to beat minnows Gibraltar (a team that has lost every tournament qualifier in its brief history) and Sweden would have to lose by seven goals to the Netherlands to miss out.
Group F: Slovakia. Currently above NI in the rankings but will fall below NI in the next update.
The two most important games in this equation, by a distance, are on Monday night - Ukraine against Croatia in Kiev and Wales against the Republic in Cardiff. So Northern Ireland need to, obviously, be above four other play-off teams in the list.
Smelly secret! The truth behind stinky durian
It was revealed that the fruit contains close to 46,000 genes - double of what humans have - which is around 23,000 genes. Scientists in Singapore recently announced they had discovered new information about durian by mapping its genome.
The short answer is yes, but in all likelihood it'll take a serious run of results to make that a reality. With five more to be confirmed, how does it leave Northern Ireland's seeding chances?
At the moment, Northern Ireland would just squeak into the seedings.
When is the World Cup play-off round draw?
Northern Ireland, if early indications are correct, will finish on 889 world ranking points. "There have been times when we have been questioned but the hunger is there, you see that in the performances".
The loss of Brady would be a major blow to Martin O'Neill's side, who are already without stand-in skipper Meyler for the first leg of the play-offs following his caution in Cardiff. It's unlikely that will be enough for a seeded spot.