Sanchez is also missing from the starting XI for Sunday's match, but is among Arsene Wenger's seven subs.
Wenger last tasted victory on the road against one of the big boys almost 1000 days ago when they saw off Manchester City 2-0 in 2015.
"We had a very positive end to last season and we played very well in games against the big teams, like Manchester City and Chelsea".
Chelsea - the Premier League champions - have been ticking over nicely since their opening weekend defeat at home to Burnley.
Chelsea midfielder Danny Drinkwater is expected to be out until the October global break. This game will mark the first in 21 years that Arsenal will have to cope with the added pressure of recuperating after a Thursday game, something which is much different than the normal Tuesday/Wednesday to Saturday structure that they were used to under the Champions League format.
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Eden Hazard looks set to start his first league game of the season.
Arsenal are likely to recall a host of first-team regulars for the short trip.
Gary Neville backed Chelsea to "bulldoze" Arsenal after Arsene Wenger's starting line-up for the clash at Stamford Bridge was confirmed. In one game, it's like that: the judgement is definite and permanent. Furthermore, the Gunners have not kept a clean sheet at Stamford Bridge in their last 12 visits.
The Gunners have lost both away games this season, including the 4-0 humiliation at Liverpool.
Arsenal may not have managed to beat Chelsea in their past five at Stamford Bridge, but they have beaten the Blues in their past two games against them.