There was also a full Premier League debut for Nick Pope in goal in place of the injured Tom Heaton, with Pope's first top-flight start coming against the backdrop of the Kop as Liverpool attacked their favourite end before the break. They have a wealth of talent at Liverpool so he is going to be limited with chances. Daniel Sturridge replaces Sadio Mane in the front three, with the Senegal worldwide serving the first of his three-match ban. However, due a combination of heroic defending from Burnley and some sheer misfortune, Klopp's side were left licking their wounds.
In their opening three away fixtures against Chelsea, Tottenham and the Reds, Burnley are unbeaten - picking up five points.
For Liverpool, their "self-fulfilling prophecy" - as the manager termed it - continues. "There will be other games, like the last one in the Champions League, where Loris Karius plays".
"We made seven changes but it was still really fluent, it looked like proper football - offensive football, dominant football, possession football how it should be", Klopp explained. You don't finish the situations. Why we feel so disappointed or frustrated is because we see what this team can do.
And those frustrations were clear for all to see inside Anfield.
"If Salah goes down. if the centre-half goes down in the 18-yard box behind the striker, and if the striker goes to the ground".
"Could Trent have won the first headed challenge?"
"When they got drinks in a little interruption, he said "OK, it's only cramp, but maybe better to stop" and we had to change this". I am sure on the global side it will be massive for Wales.
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"That's what they are working for".
Given the nature of Arfield's strike, Klopp admitted that the Reds "could have defended much better".
Liverpool allow the softest of chances, but they score the sweetest of them too.
Liverpool left-back Andy Robertson produced a crucial challenge on Arfield as the Scottish-born Canada worldwide looked to pounce on Stephen Ward's inviting cross to the near post.
Faced with a Burnley formation which on one occasion appeared to be 8-1-1, Emre Can opted for the direct route to bypass the stifling coverage and was immediately rewarded.
Sticking on the same theme, Liverpool had 30 more shots than Burnley at Anfield on Saturday.
The Brazilian had seven shots but either saw them go wide or be blocked, and had nothing on target.
Like we said, a frustrating day all around. Liverpool's defence is not good enough.