With a tree directly in front of him and needing to hit a sizeable hook off pine straw around a swath of trees, the Australian blocked his second shot into a shrub and had to take a penalty drop en route to his crippling quadruple-bogey.
Kisner has now held at least a share of the lead after all three rounds this week. The Japanese moves to seven-under, one stroke from leader Kisner. Matsuyama struggled to find the fairway off the tee, leading to a disappointing 2-over 73.
But by parring the brutally-difficult final three holes, known as the "Green Mile" with water lurking, he stayed very much in contention.
Unlike Fowler, South Korea's An Byeong-hun finished a roller-coaster round at two under after shooting a 69, which included four birdies, an eagle and four bogeys. He said at the time he had shot the stunning score despite being uncomfortable with his swing, words he repeated pre-tournament here.
Rudiger likely to start, Pedro to miss out
The phrase "120%" was the most common motif in his last address before the season begins. Lampard hasn't played competitive football since he left New York City past year .
But he recovered quickly, draining a 14m birdie bomb at the par-3 13th before backing up with another birdie on the 14th. He is now 7-under par since the end of Round 1. Louis Oosthuizen parred the ninth to post 67 and finish the round on five-under. The former British Open champion appeared to injure his wrist hitting off of a tree root on the par-4 fifth hole, but he chose to keep playing after meeting with a trainer. "If we look historically back on my career, I think I will play this tournament worse than the other three majors just in the way that it's set up", Spieth told reporters. "I'm just hitting it in the wrong spots".
Jason Day made a massive mess of the 18th. On the back nine, he had three bogeys in a row from third to fifth, before stemming the rot with a par and then closed the day with three straight birdies for a card of one-under 70 and was Tied-15th. With Sergio Garcia's popular victory at the Masters earlier this year, Fowler has in some minds inherited the dreaded title of "Best Golfer To Never Win A Major" - although Japan's Hideki Matsuyama is another strong contender for that moniker and another strong contender this weekend.
Matsuyama took advantage of greens softened by an afternoon storm, reeling off five birdies on a six-hole stretch with a series of pinpoint approach shots to card a seven-under 64, a course record in light of the redesign of Quail Hollow before the championship.
Weather delays are not uncommon on the PGA Tour and sometimes they can work for and against you.
It was his first missed cut around the world dating to last year's PGA Championship.