Damaged organs could be REGROWN with one-touch technology

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Researchers from Ohio State University call the new technology tissue nanotransfection (TNT).

According to the research, the new technology, Tissue Nanotransfection (TNT), has the capability to reprogram skin cells which can be considered a breakthrough in repairing injured or aging tissues. They claim a success rate of 98%.

In what is seen as a breakthrough in the field of regenerative medicine, Indian-origin researcher in the U.S. developed a technology that can fix organs, blood vessels and nerves by a single touch.

It takes just a fraction of a second. "It will be possible to reprogramme skin cells to harvest brain cells in a peripheral part of the body, such as the arm, which can then be injected into the brain". The first is the nanotechnology-based chip used to deliver treatment cargo to adult cells in the living body. A small, barely detectable electric pulse stimulates the existing cells.

Despite its explosive connotations, TNT isn't a particularly invasive process: it can be administered at the point of care and doesn't require lab-based procedures.

The paper describes experiments on mice and pigs.

In a series of lab tests, the Researchers applied the chip to the injured legs of mice that vascular scans revealed had minimal to no blood flow.

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The technology Tissue Nanotransfection can fix injured legs with just one touch. Within a fortnight flow was back within normal parameters.

In another application, the technology was used on an injured brain and helped mice recover from a stroke.

Chandan Sen, director of the Center for Regenerative Medicine and Cell-Based Therapies, said that now, the technology not only works on skin cells, but can also fix other types of tissue.

Dr. Chandan Sen, who led the study said, "With this technology, we can convert skin cells into elements of any organ with just one touch".

"The concept is very simple", says L. James Lee, a professor of chemical and biomolecular engineering with Ohio State's College of Engineering.

"What's even more exciting is that it not only works on the skin, but on any type of tissue", Sen said.

Since the method uses a patient's own cells and does not depend upon medication, the Researchers anticipate it to be approved for human trials by the end of the year.

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